Article

The endoplasmic reticulum autophagy receptor TEX264 drives epidermal differentiation and is dysregulated in Darier disease

2025-08-07

Abstract excerpt

<h4>ABSTRACT</h4> Differentiating keratinocytes break down their organelles and nuclei to become the compacted cornified layers of the epidermal barrier in a poorly understood catabolic process. Live confocal imaging of stratified human organotypic epidermis revealed endoplasmic reticulum (ER) fragmentation and lysosomal engulfment in the cornifying layers, where we found up-regulation of TEX264, a receptor that...

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Literature Corpus work: 9eb3df12-3465-5889-a8cf-3d71f068cbad
DOI: 10.1101/2025.08.05.668774

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