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A multi-tiered μDicer with hierarchical blades achieves protein-preserving microdissection down to 10 μm

2025-12-16

Abstract excerpt

<h4>ABSTRACT</h4> To study tissue heterogeneity at the sub-millimeter scale, laser capture microdissection (LCM) has been the leading technology for isolating regions of interest (ROI) for downstream molecular profiling. As the ROI approaches cellular dimensions (∼10 μm), laser-induced photothermal damage and challenges in capturing microtissues in conventional LCM can compromise protein preservation and quantita...

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Literature Corpus work
9ea08238-70bd-5743-9940-9ec2294fd312
DOI
10.64898/2025.12.12.694048
Open publication

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A multi-tiered μDicer with hierarchical blades achieves protein-preserving microdissection down to 10 μmDOI 10.64898/2025.12.12.694048
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