Article

Cell-type-resolved spatial proteogenomics from matched genome and proteome of the same cells

2026-07-10

Abstract excerpt

The genome and proteome of the same cells are rarely measured together, which is especially consequential in cancer, where somatic mutations vary across clones and drive disease. We show that a single standard proteomics extraction tip can retain peptides on-tip after digestion while genomic DNA passes into the normally discarded flowthrough. Combined with Deep Visual Proteomics, flowthrough co-isolation enables c...

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Literature Corpus work: ef194545-0cc3-537b-9db4-6aca787da2bf
DOI: 10.64898/2026.07.09.737478

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