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A large-scale multi-omics polygenic risk score analysis identified candidate risk locus associated with rheumatoid arthritis.

Joint bone spine - 1 May 2025

Hui Jingni, He Dan, Liu Chen, Shi Panxing, Zhou Ruixue, Kang Meijuan, Liu Ye, Gou Yifan, Wang Bingyi, Cheng Shiqiang, Yang Xuena, Pan Chuyu, Wei Wenming, Zhang Feng

Abstract excerpt

OBJECTIVE: This study aimed to investigate the associations of multi-omics polygenic risk score (PRS) and rheumatoid arthritis (RA) to identify potential genes/proteins and biological pathways. METHODS: Based on multi-omics data from 48,813 participants in the INTERVAL cohort, we calculated multi-omics PRS for 13,646 mRNAs (RNASeq), 308 proteins (Olink), 2380 proteins (SomaScan), 726 metabolites (Metabolon), and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39732430
DOI: 10.1016/j.jbspin.2024.105841

Genes

ABCF1
AGER
FLOT1
TFF3

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