Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Etiology of Exfoliation Syndrome

Abstract excerpt

<title>Abstract</title> <p>Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is the most common cause of secondary glaucoma, resulting in widespread global blindness. We performed Transcriptomic Wide Association Studies using PrediXcan models trained in 4...

Topics

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• Amino Acid Oxidoreductases
• DNA-Binding Proteins
• Exfoliation Syndrome
• Gene Expression
• Glaucoma and retinal disorders
• Mutation, Missense
• Polymorphism, Single Nucleotide
• RNA, Messenger

Identifiers and source

Literature Corpus work

9e646c41-411c-5d63-9319-4778d88fb408

DOI

10.21203/rs.3.rs-53203/v1