Analysis of Genetically Determined Gene Expression Suggests Role of Inflammatory Processes in Exfoliation Syndrome

Abstract excerpt

Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is the most common cause of secondary glaucoma, resulting in widespread global blindness. We performed Transcriptomic Wide Association Studies (TWAS) using PrediXcan models trained in 48 GTEx tissues to ide...

Topics

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• Amino Acid Oxidoreductases
• DNA-Binding Proteins
• Exfoliation Syndrome
• Gene Expression
• Glaucoma and retinal disorders
• Mutation, Missense
• Polymorphism, Single Nucleotide
• RNA, Messenger

Identifiers and source

Literature Corpus work

c3cf1458-dd8f-54c6-80ce-a4fbce289be6

DOI

10.1101/2020.12.17.423318