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Article

Analysis of genetically determined gene expression suggests role of inflammatory processes in exfoliation syndrome.

BMC genomics - 16 Feb 2023

Hirbo Jibril B, Pasutto Francesca, Gamazon Eric R, Evans Patrick, Pawar Priyanka, Berner Daniel, Sealock Julia, Tao Ran, Straub Peter S, Konkashbaev Anuar I, Breyer Max A, Schlötzer-Schrehardt Ursula, Reis André, Brantley Milam A, Khor Chiea C, Joos Karen M, Cox Nancy J

Abstract excerpt

BACKGROUND: Exfoliation syndrome (XFS) is an age-related systemic disorder characterized by excessive production and progressive accumulation of abnormal extracellular material, with pathognomonic ocular manifestations. It is the most common cause of secondary glaucoma, resulting in widespread global blindness. The largest global meta-analysis of XFS in 123,457 multi-ethnic individuals from 24 countries...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36797672
DOI: 10.1186/s12864-023-09179-7
PMCID: PMC9936777

Genes

LOXL1
ARID3B
CD276
NEO1
SCAMP2
UBL7

Provenance

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