Article

Deep phenotypic profiling of neuroactive drugs in larval zebrafish

2024-02-25

Abstract excerpt

Behavioral larval zebrafish screens leverage a high-throughput small molecule discovery format to find neuroactive molecules relevant to mammalian physiology. We screened a library of 650 central nervous system active compounds in high replicate to train a deep metric learning model on zebrafish behavioral profiles. The machine learning initially exploited subtle artifacts in the phenotypic screen, necessitating a...

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Literature Corpus work: 9e3cb344-b116-509b-a702-faace79917b4
DOI: 10.1101/2024.02.22.581657

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