Article

Non cell-autonomous effect of astrocytes on cerebral cavernous malformations

2021-02-01

Abstract excerpt

Cerebral cavernous malformations (CCMs) are common neurovascular lesions caused by loss-of-function mutations in one of three genes, including KRIT1 (CCM1), CCM2 , and PDCD10 (CCM3), and generally regarded as an endothelial cell-autonomous disease. Here we report that proliferative astrocytes play a critical role in CCM pathogenesis by serving as a major source of VEGF during CCM lesion formation. An increase i...

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Literature Corpus work: 9e284109-2b3a-5a95-9311-94aed5ee7bda
DOI: 10.1101/2021.01.29.428891

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