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CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human Cells

14 Mar 2023

Abstract excerpt

Toxoplasma infection causes serious complications in immunocompromised individuals and in the developing fetus. During infection, certain immune cells release a protein called interferon gamma that activates cells to destroy the parasite or inhibit its growth.

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Identifiers

PMID: 36916910
DOI: 10.1128/mbio.00060-23

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CRISPR Screens Identify Toxoplasma Genes That Determine Parasite Fitness in Interferon Gamma-Stimulated Human CellsPMID 36916910Read ↗

A genome-wide loss-of-function screen identifies <i>Toxoplasma gondii</i> genes that determine fitness in interferon gamma-activated murine macrophagesSemantic proximity Read ↗

Cell-based screen identifies human type I interferon-stimulated regulators of <i>Toxoplasma gondii</i> InfectionSemantic proximity Read ↗

Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophagesSemantic proximity Read ↗

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A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan GenesSemantic proximity Read ↗

Efficient Genome Engineering of Toxoplasma gondii Using CRISPR/Cas9Semantic proximity Read ↗

Genome-Wide CRISPR Screen Identifies Host Factors Required by Toxoplasma gondii InfectionSemantic proximity Read ↗

Over-expression Screen of Interferon-Stimulated Genes Identifies RARRES3 as a Restrictor of <i>Toxoplasma gondii</i> InfectionSemantic proximity Read ↗

Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infectionSemantic proximity Read ↗

Optimizing Systems for Cas9 Expression in Toxoplasma gondiiSemantic proximity Read ↗

Genome-wide and targeted CRISPR screens identify RNF213 as a mediator of interferon gamma–dependent pathogen restriction in human cellsSemantic proximity Read ↗

Toxoplasma gondii Dysregulates IFN-γ-Inducible Gene Expression in Human Fibroblasts: Insights from a Genome-Wide Transcriptional ProfilingSemantic proximity Read ↗

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