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Article

IL-13Rα2 Membrane and Soluble Isoforms Differ in Humans and Mice

1 Dec 2009

Abstract excerpt

Although mice have nanogram per milliliter serum levels of soluble (s) IL-13Ralpha2, humans lack sIL-13Ralpha2 in serum. Our data provide a mechanism for this biological divergence. In mice, discrete transcripts encoding soluble and membrane forms of IL-13Ralpha2 are generated by alternative splicing. We used small interfering RNA to specifically deplete the transcript encoding membrane (mem) IL-13Ralpha2...

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PMID: 20007572
DOI: 10.4049/jimmunol.0901028

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