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Article

Type II TGFβ receptor modulates chondrocyte phenotype.

Age (Dordrecht, Netherlands) - 1 Aug 2013

Baugé Catherine, Duval Elise, Ollitrault David, Girard Nicolas, Leclercq Sylvain, Galéra Philippe, Boumédiene Karim

Abstract excerpt

Aging is one of the major risk factors of osteoarthritis. This pathology during which chondrocytes undergo modifications of their phenotype may result from alteration of transforming growth factor β (TGFβ) signaling. This study investigates the role of TGFβ response in the process of chondrocyte dedifferentiation/redifferentiation. Dedifferentiation was induced by successive passages of human articular...

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Share to Aging
Share to Blotting, Western
Share to Cartilage, Articular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Disease Progression

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Share to Real-Time Polymerase Chain Reaction

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Source

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Identifiers

PMID: 22653295
DOI: 10.1007/s11357-012-9433-7
PMCID: PMC3705098

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