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Article

Overexpression of Akt converts radial growth melanoma to vertical growth melanoma.

The Journal of clinical investigation - 1 Mar 2007

Govindarajan Baskaran, Sligh James E, Vincent Bethaney J, Li Meiling, Canter Jeffrey A, Nickoloff Brian J, Rodenburg Richard J, Smeitink Jan A, Oberley Larry, Zhang Yuping, Slingerland Joyce, Arnold Rebecca S, Lambeth J David, Cohen Cynthia, Hilenski Lu, Griendling Kathy, Martínez-Diez Marta, Cuezva José M, Arbiser Jack L

Abstract excerpt

Melanoma is the cancer with the highest increase in incidence, and transformation of radial growth to vertical growth (i.e., noninvasive to invasive) melanoma is required for invasive disease and metastasis. We have previously shown that p42/p44 MAP kinase is activated in radial growth melanoma,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neovascularization, Pathologic

Share to Proto-Oncogene Proteins c-akt

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Source

Open in PubMed Open full text

Identifiers

PMID: 17318262
DOI: 10.1172/JCI30102
PMCID: PMC1797605

Genes

NOX4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17318262-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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