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Article

The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation.

Cancer cell - 1 Dec 2005

Bedogni Barbara, Welford Scott M, Cassarino David S, Nickoloff Brian J, Giaccia Amato J, Powell Marianne Broome

Abstract excerpt

Constitutive activation of Akt characterizes a high percentage of human melanomas and represents a poor prognostic factor of the disease. We show that Akt transforms melanocytes only in a hypoxic environment, which is found in normal skin. The synergy between Akt and hypoxia is HIF1alpha mediated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 16338658
DOI: 10.1016/j.ccr.2005.11.005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16338658-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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