Article

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

2020-02-04

Abstract excerpt

Circulating levels of small molecules or metabolites are highly heritable, but the impact of genetic differences in metabolism on human health is not well understood. In this cross-platform, genome-wide meta-analysis of 174 metabolite levels across six cohorts including up to 86,507 participants (70% unpublished data), we identify 499 (362 novel) genome-wide significant associations (p<4.9×10 -10 ) at 144 (94 nov...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9dcfd613-e765-5150-b4e8-a1db61e42b84
DOI: 10.1101/2020.02.03.932541

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomesDOI 10.1101/2020.02.03.932541Read

A cross-platform approach identifies genetic regulators of human metabolism and health.Semantic proximity Read

Convergent human genetic evidence implicates serine biosynthesis in diabetic peripheral neuropathySemantic proximity Read

Rare and common genetic determinants of metabolic individuality and their effects on human health.Semantic proximity Read

Integration of Genome-Wide SNP Data and Gene-Expression Profiles Reveals Six Novel Loci and Regulatory Mechanisms for Amino Acids and Acylcarnitines in Whole Blood.Semantic proximity Read

Genome-wide association study for circulating metabolic traits in 619,372 individualsSemantic proximity Read

Analysis of whole genome sequencing and plasma metabolomics unveil genetic determinants and clinical implications for human health.Semantic proximity Read

A genetic map of human metabolism across the allele frequency spectrumSemantic proximity Read

Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.Semantic proximity Read

Whole Exome Sequencing Enhanced Imputation Identifies 85 Metabolite Associations in the Alpine CHRIS CohortSemantic proximity Read

Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.Semantic proximity Read

Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites.Semantic proximity Read

Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Semantic proximity Read