Article

Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature

2020-12-04

Abstract excerpt

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, a transcriptional analysis of lesions from patients identified the presence of a strong interferon stimulated gene (ISG) signature. To...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bf900562-5298-51e7-b79c-9d841b81e9a0
DOI: 10.1101/2020.12.03.20240978

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signatureDOI 10.1101/2020.12.03.20240978Read

Transcriptome Patterns from Primary Cutaneous Leishmania braziliensis Infections Associate with Eventual Development of Mucosal Disease in HumansSemantic proximity Read

Spatial transcriptomics landscape of lesions from non-communicable inflammatory skin diseasesSemantic proximity Read

Spatial mapping of Ethiopian cutaneous leishmaniasis lesions reveals distinct tissue level immune programsSemantic proximity Read

A new paradigm for leprosy diagnosis based on host gene expression Insights from leprosy lesions transcriptomicsSemantic proximity Read

In vivo reprogramming of murine host immune response genes following Leishmania major infectionSemantic proximity Read

A new paradigm for leprosy diagnosis based on host gene expressionSemantic proximity Read

In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolutionSemantic proximity Read

Innate biosignature of treatment failure in human cutaneous leishmaniasisSemantic proximity Read

Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantumSemantic proximity Read

Single cell immunophenotyping identifies CD8 <sup>+</sup> GZMK <sup>+</sup> IFNG <sup>+</sup> T cells as a key immune population in cutaneous Lyme diseaseSemantic proximity Read

Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensisSemantic proximity Read

Spatial transcriptomics reveals organized and distinct immune activation in cutaneous granulomatous disordersSemantic proximity Read