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Tuberculosis and the art of macrophage manipulation

11 Apr 2018

Abstract excerpt

Macrophages are first-line responders against microbes. The success of Mycobacterium tuberculosis (Mtb) rests upon its ability to convert these antimicrobial cells into a permissive cellular niche. This is a remarkable accomplishment, as the antimicrobial arsenal of macrophages is extensive. Normally bacteria are delivered to an acidic, degradative lysosome through one of several trafficking pathways, including...

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PMID: 29762680
DOI: 10.1093/femspd/fty037

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