Article

Stage-specific CHI3L1/YKL-40 signaling controls generation of oligodendrocyte precursor cells through IL13Rα2-mediated ferroptosis

2026-05-12

Abstract excerpt

Oligodendrocyte precursor cells (OPCs) are essential for sustaining myelin plasticity and maintaining oligodendroglial homeostasis throughout life. However, the intrinsic signaling mechanisms that regulate OPC generation from neural progenitors remain incompletely understood. Here, we identify chitinase-3-like protein 1 (CHI3L1/YKL-40) as a stage-specific, intrinsic signaling regulator of oligodendroglial lineage...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d815aa5-ebe1-5d99-9be5-1e21f9126023
DOI: 10.64898/2026.05.08.723841

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stage-specific CHI3L1/YKL-40 signaling controls generation of oligodendrocyte precursor cells through IL13Rα2-mediated ferroptosisDOI 10.64898/2026.05.08.723841Read

Injury-transduced SerpinOLs modulate neuroinflammation and glial activation in the diseased and non-diseased CNSSemantic proximity Read

Differential Regulation of Hepatic Macrophage Fate by Chi3l1 in MASLDSemantic proximity Read

Hippocampal multi-layered RNAseq prioritizes oligodendrocyte dysfunction over immune–driven neuroinflammation in neurolupus pathogenesisSemantic proximity Read

A Human iPSC-derived Organoid System to Model Myelin Destruction and RepairSemantic proximity Read

Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and DiseaseSemantic proximity Read

Interleukin-33 from oligodendrocytes sustains effector differentiation of tissue-resident CD8+ T cells and is a druggable target in CNS autoimmune diseaseSemantic proximity Read

Cerebral organoids in primary progressive multiple sclerosis reveal stem cell and oligodendrocyte differentiation defectSemantic proximity Read

Autophagy in Oligodendrocyte Lineage Cells Controls Oligodendrocyte Numbers and Myelin Integrity in an Age-dependent MannerSemantic proximity Read

Astrocytic Chitinase‐3‐like protein 1 in neurological diseases: Potential roles and future perspectivesSemantic proximity Read

Neuroinflammatory disease signatures in SPG11-related hereditary spastic paraplegia patients.Semantic proximity Read

Oligodendrocyte Progenitor Cells Increase Chi3l1 Secretion in Exosome to Activate Myh9 and Promote Proliferation through Connexin47 Connected to AstrocytesSemantic proximity Read

Oligodendrocyte Progenitor Cells Increase Chi3l1 Secretion in exosome to Activate Myh9 and Promote Proliferation through Connexin47 Connected to AstrocytesSemantic proximity Read