Article

ADAR1 Restricts Poliovirus Infection through dual disruption of translation initiation and protein coding

2025-06-23

Abstract excerpt

<h4>Summary</h4> Viral RNAs (vRNAs) interact with hundreds of host proteins, but how these interactions shape viral infection remains largely unknown. Here we developed a mass-spectrometry approach to identify cellular RNA-binding proteins (RBPs) that enhance or inhibit infection by modulating vRNA translation. We identified 130 RBPs that associate with polysomes in human cells infected with poliovirus, including...

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Identifiers and source

Literature Corpus work: 9d44dbf2-c35c-5ba8-af49-42d46b44432a
DOI: 10.1101/2025.06.19.660622

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