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Article

Global Reprogramming of the Cellular Translational Landscape Facilitates Cytomegalovirus Replication

1 Jan 2014

Abstract excerpt

Unlike many viruses that suppress cellular protein synthesis, host mRNA translation and polyribosome formation are stimulated by human cytomegalovirus (HCMV). How HCMV impacts the translationally regulated cellular mRNA repertoire and its contribution to virus biology remains unknown. Using polysome profiling, we show that HCMV presides over the cellular translational landscape, selectively accessing the host...

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PMID: 24373965
DOI: 10.1016/j.celrep.2013.11.045

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