Article

Multiscale mapping of transcriptomic signatures for cardiotoxic drugs

2021-11-04

Abstract excerpt

Drug-induced gene expression profiles can identify potential mechanisms of toxicity. We focused on obtaining signatures for cardiotoxicity of FDA-approved tyrosine kinase inhibitors (TKIs) in human induced pluripotent stem cell-derived cardiomyocytes. Using bulk transcriptomics profiles, we applied singular value decomposition to identify drug-selective patterns in cell lines obtained from multiple healthy human s...

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Literature Corpus work: 54436b25-361e-59a3-8141-2eaa82df99e9
DOI: 10.1101/2021.11.02.466774

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