Back to search

Article

The mechanism of atorvastatin-induced sarcopenia elucidated based on network toxicology, single-cell RNA sequencing, and bulk transcriptomics data

2026-03-10

Abstract excerpt

<title>Abstract</title> <p>Background Sarcopenia (SA) significantly affects the quality of life in the elderly. Atorvastatin (ATS), a lipid-lowering drug, may cause myopathy as a side effect. This study aimed to predict key genes involved in ATS-induced SA using network. Methods Public databases were used to obtain single-cell RNA sequencing (scRNA-seq) data, transcriptome data, and targets for SA and ATS toxic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8721c988-9c3a-5834-90bd-c9af5bd71960
DOI
10.21203/rs.3.rs-9058922/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
The mechanism of atorvastatin-induced sarcopenia elucidated based on network toxicology, single-cell RNA sequencing, and bulk transcriptomics dataDOI 10.21203/rs.3.rs-9058922/v1
Key Genes, Altered Pathways and Potential Treatments for Muscle Loss in Astronauts and Sarcopenic PatientsSemantic proximity
Epigenetic characterization of sarcopenia-associated genes based on machine learning and network screeningSemantic proximity
A machine learning-derived gene signature of programmed cell death reveals diagnostic biomarkers in dilated cardiomyopathySemantic proximity
Integrative bulk and single-cell transcriptome analyses reveal mitochondria and immune-related biomarkers in atherosclerosis with experimental validationSemantic proximity
Identification of novel biomarkers and drug targets for frailty-related skeletal muscle aging: a multi-omics studySemantic proximity
Identification of potential crucial genes in sarcopenia: a bioinformatic analysisSemantic proximity
Predictive models of sarcopenia based on inflammation and pyroptosis-related genesSemantic proximity
Molecular Network Analysis and Effector Gene Prioritization of Endurance Training–Influenced Modulation of Cardiac AgingSemantic proximity
Combining Network Toxicology with Machine Learning and Experiment Validation to Analyze the Molecular Mechanism and Core Target Screening of Aristolochic Acid NephropathySemantic proximity
Identification and experimental validation of biomarkers associated with exercise in intervertebral disc degeneration through bulk RNA and single-cell RNA sequencing analysisSemantic proximity
Identification of biomarkers associated with endoplasmic reticulum stress-related cell death in osteoporosis based on bulk and single-cell transcriptomic analyses and experimental validationSemantic proximity
Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for sarcopenia.Semantic proximity
Select a neighboring publication to make it the new centre.