Article

T-cell receptors identified by a personalized antigen-agnostic screening approach target shared neoantigen KRAS Q61H

2024-09-21

Abstract excerpt

Adoptive cell therapy (ACT) with TCR-engineered T-cells represents a promising alternative to TIL- or CAR-T therapies for patients with advanced solid cancers. Currently, selection of therapeutic TCRs critically depends on knowing the target antigens, a condition excluding most patients from treatment. Direct antigen-agnostic identification of tumor-specific T-cell clonotypes and TCR-T manufacturing using their TC...

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Literature Corpus work: 9d36cced-43ef-5e9c-83d5-ddee3c195222
DOI: 10.1101/2024.09.19.612910

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