Article
Identification of novel KRASG12D neoantigen specific TCRs and a strategy to eliminate off-target recognition.
Journal of translational medicine - 17 Jan 2025
Han Xiaojian, Han Xiaxia, Hao Yanan, Wang Bozhi, Li Luo, Chen Siyin, Zou Lin, Huang Jingjing, Chen Tong, Wang Wang, Liu Shengchun, Jin Aishun, Shen Meiying
Abstract excerpt
BACKGROUND: T cell receptor (TCR)-engineered T cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes in clinical trials against solid tumors. However, the challenge lies in developing tumor-specific TCRs that avoid cross-reactivity with self-antigens to minimize the possibility of severe clinical toxicities. Current research efforts have been put towards...
Read the complete abstract on PubMedTopics
- Humans
- Receptors, Antigen, T-Cell
- Proto-Oncogene Proteins p21(ras)
- Jurkat Cells
- Antigens, Neoplasm