Article

Adoptive cell therapy targeting common p53 neoantigens in human solid cancers

2021-09-24

Abstract excerpt

<title>Abstract</title> <p>Adoptive cell therapy (ACT) targeting neoantigens can achieve durable clinical responses in patients with cancer. Most neoantigens arise from rare mutations, requiring highly individualized treatments. To broaden the applicability of ACT targeting neoantigens, we focused on <italic>TP53</italic> mutations commonly shared across different cancer types. Here, we describe a library of T ce...

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Literature Corpus work: 379a5011-ab43-5cda-8cdf-759af5c40931
DOI: 10.21203/rs.3.rs-916555/v1

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