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Generation of T cell responses against broad KRAS hotspot neoantigens for cell therapy or TCR discovery

1 May 2025

Abstract excerpt

Adoptive cell therapy (ACT) with T cells targeting Kirsten rat sarcoma (KRAS) neoantigens can drive anti-tumor immunity but has so far been focused on a small fraction of known KRAS neoantigens. Here, we develop a single process starting from peripheral blood that can prime and expand T cell responses ex vivo to any KRAS neoantigen based on each individual's human leukocyte antigen (HLA) profile. We conducted the...

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PMID: 40359936
DOI: 10.1016/j.crmeth.2025.101049

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