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Article

Epidermal growth factor receptor mutations in breast Cancer: Therapeutic challenges and way forward.

Bioorganic chemistry - 1 Jan 2025

Shetty Swathi R, Kar Trisha, Das Amitava

Abstract excerpt

Epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase (RTK) that is upregulated in aggressive triple-negative breast cancer (TNBC). Ligands such as EGF, TGF-α, epigen, and amphiregulin activate the auto-phosphorylation activity of tyrosine residues on EGFR, which regulates the growth, proliferation, adhesion, migration, and survival of cancer cells. Our prior studies depicted that inhibition of...

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Identifiers

PMID: 39672077
DOI: 10.1016/j.bioorg.2024.108037

Genes

EGFR
EGF

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