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Article

A Comprehensive Review of HER2 in Cancer Biology and Therapeutics

11 Jul 2024

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial role in cell proliferation, survival, and differentiation. Aberrant HER2 signaling is implicated in various cancers, particularly in breast and gastric cancers, where HER2 overexpression or amplification correlates with aggressive tumor behavior...

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Identifiers

PMID: 39062682
DOI: 10.3390/genes15070903

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