Molecular Targeting the Human Epidermal Growth Factor Receptor-2 (HER2) Genes Across Various Cancer

Abstract excerpt

Human epidermal growth factor receptor 2 (HER2) belongs to the ErbB family, a group of four transmembrane glycoproteins with tyrosine kinase activity, all structurally related to the epidermal growth factor receptor (EGFR). These tyrosine kinases are involved in the transmission of cellular signals controlling normal cell growth and differentiation. If this transmission goes awry, it can lead to dysregulated growt...

Topics

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• Computational Drug Discovery Methods
• Disease Progression
• Drug Resistance, Neoplasm
• ErbB Receptors
• HER2/EGFR in Cancer Research
• Molecular Targeted Therapy
• Monoclonal and Polyclonal Antibodies Research
• Receptor, ErbB-2

Identifiers and source

Literature Corpus work

4ede3402-131c-5c14-97f1-aa53918099ff

DOI

10.20944/preprints202312.0982.v1