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Article

MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis.

Cell death & disease - 10 Nov 2022

Zou Xiaodong, Ouyang Hongsheng, Lin Feng, Zhang Huanyu, Yang Yang, Pang Daxin, Han Renzhi, Tang Xiaochun

Abstract excerpt

Genetic mutations in the MYBPC3 gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy (HCM). Myocardial fibrosis (MF) plays a critical role in the development of HCM. However, the mechanism for mutant MYBPC3-induced MF is not well defined. In this study, we developed a R495Q mutant pig model using cytosine base editing and observed an early-onset MF in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36357371
DOI: 10.1038/s41419-022-05403-6
PMCID: PMC9649783

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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