Article

Homology-Directed Repair of an MYBPC3 gene mutation in a rat model of hypertrophic cardiomyopathy

2022-11-15

Abstract excerpt

<title>Abstract</title> <p>Variants in myosin-binding protein C3 (<italic>MYBPC3</italic>) gene are a main cause of hypertrophic cardiomyopathy (HCM), accounting for 30–40% of the total number of HCM cases. Gene editing represents a potential permanent cure for HCM. The aim of this study was to investigate whether genome editing of <italic>MYBPC3</italic> using the CRISPR/Cas9 system <italic>in vivo</italic> coul...

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Literature Corpus work: 8226034a-269e-585d-a922-e1e585675159
DOI: 10.21203/rs.3.rs-2199328/v1

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