Article

Synaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal Neurons

2024-01-22

Abstract excerpt

Cortical layer 5 (L5) intratelencephalic (IT) and pyramidal tract (PT) neurons are embedded in distinct information processing pathways. The morphology, connectivity, electrophysiological properties, and role in behavior of these neurons have been extensively analyzed. However, the molecular composition of their synapses remains largely uncharacterized. Here, we dissect the protein composition of the excitatory po...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d009228-6916-511a-b854-92dcd7c5fe45
DOI: 10.1101/2024.01.22.576602

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Synaptic Signatures and Disease Vulnerabilities of Layer 5 Pyramidal NeuronsDOI 10.1101/2024.01.22.576602Read

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease relevant pathologiesSemantic proximity Read

Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.Semantic proximity Read

Pyramidal neurons proportionately alter cortical interneuron subtypes.Semantic proximity Read

Synaptic proteomics reveal distinct molecular signatures of cognitive change and C9ORF72 repeat expansion in the human ALS cortexSemantic proximity Read

Synaptic proteomics reveal distinct molecular signatures of cognitive change and<i>C9ORF72</i>repeat expansion in the human ALS cortexSemantic proximity Read

The human and mouse synaptome architecture of excitatory synapses show conserved featuresSemantic proximity Read

Glutamate synapses in human cognitive disorders.Semantic proximity Read

SynaptopathyDB: a resource for studying the genetic and synaptic basis of nervous system disordersSemantic proximity Read

Synaptic protein mutations in autism.Semantic proximity Read

Autism-associated <i>SCN2A</i> deficiency disrupts cortico-striatal circuitry in human brain assembloidsSemantic proximity Read

Data-driven synapse classification reveals a logic of glutamate receptor diversitySemantic proximity Read

Polygenic Dissection of Synaptic Pruning and Glutamatergic Signaling: Contrasting Mechanisms in ASD and ADHDSemantic proximity Read