Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophy

16 Feb 2011

Abstract excerpt

Cardiac hypertrophy, the adaptive response of the heart to overload, is a major risk factor for heart failure and sudden death. Estrogen (E2) and estrogen receptor beta (ERbeta) offer protection against hypertrophy and in the transition to heart failure. However, the underlying pathways remain incompletely defined. We employed a publicly available microarray dataset of female wild-type (WT) and ERbeta knockout...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Fibrosis and Remodeling
Share to Estrogen and related hormone effects
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21325064
DOI: 10.1152/physiolgenomics.00199.2010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the estrogen/estrogen-receptor-beta axis in the genomic response to pressure overload-induced hypertrophyPMID 21325064Read ↗

Comparative Proteomic Analysis Reveals Sex and Estrogen Receptor β Effects in the Pressure Overloaded HeartSemantic proximity Read ↗

Estrogen-related receptor gamma induces cardiac hypertrophy by activating GATA4.Semantic proximity Read ↗

Transcriptome profiling reveals novel BMI- and sex-specific gene expression signatures for human cardiac hypertrophySemantic proximity Read ↗

Sex-specific regulation of cardiac microRNAs targeting mitochondrial proteins in pressure overloadSemantic proximity Read ↗

Sex-specific cardioprotective role of miR-30a-5p through estrogen-dependent mechanisms in a mouse model of heart failure.Semantic proximity Read ↗

Suppression of ERR targets by a PPARα/Sirt1 complex in the failing heartSemantic proximity Read ↗

Transcriptome Characterization of Estrogen-Treated Human Myocardium Identifies Myosin Regulatory Light Chain Interacting Protein as a Sex-Specific Element Influencing Contractile FunctionSemantic proximity Read ↗

Female rats with severe left ventricle volume overload exhibit more cardiac hypertrophy but fewer myocardial transcriptional changes than malesSemantic proximity Read ↗

Upregulation of key genes Eln and Tgfb3 were associated with the severity of cardiac hypertrophySemantic proximity Read ↗

BET Protein-Mediated Transcriptional Regulation in Heart FailureSemantic proximity Read ↗

Sex- and estrogen-dependent regulation of a miRNA network in the healthy and hypertrophied heartSemantic proximity Read ↗

Differential activation of P-TEFb complexes in the development of cardiomyocyte hypertrophy following activation of distinct GPCRsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.