Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.

PloS one - 21 Sept 2010

Rujoi Madalina, Pipalia Nina H, Maxfield Frederick R

Abstract excerpt

BACKGROUND: Niemann-Pick type C (NPC) disease is a genetically inherited multi-lipid storage disorder with impaired efflux of cholesterol from lysosomal storage organelles. METHODOLOGY/PRINCIPAL FINDINGS: The effect of screen-selected cholesterol lowering compounds on the major sterol pathways was studied in CT60 mutant CHO cells lacking NPC1 protein. Each of the selected chemicals decreases cholesterol in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticholesteremic Agents
Share to Drug Evaluation, Preclinical

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoproteins

Share to Lysosomes

Share to Niemann-Pick C1 Protein

Share to Niemann-Pick Diseases

Share to Small Molecule Libraries

Share to Sterols

Source

Open in PubMed Open full text

Identifiers

PMID: 20877719
DOI: 10.1371/journal.pone.0012788
PMCID: PMC2943465

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cholesterol pathways affected by small molecules that decrease sterol levels in Niemann-Pick type C mutant cells.PMID 20877719Read ↗

Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells.Semantic proximity Read ↗

Niemann-Pick type C disease: molecular mechanisms and potential therapeutic approaches.Semantic proximity Read ↗

Identification of a pharmaceutical compound that partially corrects the Niemann-Pick C phenotype in cultured cells.Semantic proximity Read ↗

Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C Disease.Semantic proximity Read ↗

Screening of small molecule chemical library identifies leads that reduce cholesterol accumulation in human NPC1 fibroblastsSemantic proximity Read ↗

Chemical screen to reduce sterol accumulation in Niemann-Pick C disease cells identifies novel lysosomal acid lipase inhibitors.Semantic proximity Read ↗

Inhibition of acid ceramidase as a therapeutic strategy for Niemann-Pick C diseaseSemantic proximity Read ↗

Mechanisms and consequences of impaired lipid trafficking in Niemann-Pick type C1-deficient mammalian cells.Semantic proximity Read ↗

Quantitative comparison of the efficacy of various compounds in lowering intracellular cholesterol levels in Niemann-Pick type C fibroblasts.Semantic proximity Read ↗

Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapiesSemantic proximity Read ↗

Autophagy in Niemann–Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defectsSemantic proximity Read ↗

Finding pathogenic commonalities between Niemann-Pick type C and other lysosomal storage disorders: Opportunities for shared therapeutic interventions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.