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Article

Recovery from liver disease in a Niemann-Pick type C mouse model.

Journal of lipid research - 1 Aug 2010

Sayre Naomi L, Rimkunas Victoria M, Graham Mark J, Crooke Rosanne M, Liscum Laura

Abstract excerpt

Loss of function of Niemann-Pick C1 (NPC1) leads to lysosomal free cholesterol storage, resulting in the neurodegenerative disease Niemann-Pick disease type C (NPC). Significant numbers of patients with NPC also suffer from liver disease. Currently, no treatments exist that alter patient outcome, and it is unknown if recovery from tissue damage can occur even if a treatment were found. Our laboratory developed a...

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Source

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Identifiers

PMID: 20418540
DOI: 10.1194/jlr.M007211
PMCID: PMC2903820

Genes

NPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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