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Article

A commensal-derived sugar protects against obesity by regulating immunometabolism

2024-06-12

Abstract excerpt

<h4>SUMMARY</h4> Obesity is a worsening global epidemic that is regulated by the microbiota through unknown bacterial factors. We discovered a human commensal bacterium, Clostridium immunis , that treats obesity by secreting a phosphocholine-modified exopolysaccharide. Loss- and gain-of-function bacterial mutants involving the phosphocholine biosynthesis locus ( licABC ) revealed the phosphocholine moiety is cr...

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Literature Corpus work
1f040487-d367-56f5-9933-960c1d1d77b8
DOI
10.1101/2024.06.12.598703
Open publication

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A commensal-derived sugar protects against obesity by regulating immunometabolismDOI 10.1101/2024.06.12.598703
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