Article
Production of α-galactosylceramide by a prominent member of the human gut microbiota.
PLoS biology - 1 Jul 2013
Wieland Brown Laura C, Penaranda Cristina, Kashyap Purna C, Williams Brianna B, Clardy Jon, Kronenberg Mitchell, Sonnenburg Justin L, Comstock Laurie E, Bluestone Jeffrey A, Fischbach Michael A
Abstract excerpt
While the human gut microbiota are suspected to produce diffusible small molecules that modulate host signaling pathways, few of these molecules have been identified. Species of Bacteroides and their relatives, which often comprise >50% of the gut community, are unusual among bacteria in that their membrane is rich in sphingolipids, a class of signaling molecules that play a key role in inducing apoptosis and...
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