Article
Insights into β-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.
The Journal of biological chemistry - 28 Jun 2013
Papp-Wallace Krisztina M, Taracila Magdalena A, Gatta Julian A, Ohuchi Nozomi, Bonomo Robert A, Nukaga Michiyoshi
Abstract excerpt
Burkholderia cepacia complex and Burkholderia pseudomallei are opportunistic human pathogens. Resistance to β-lactams among Burkholderia spp. is attributable to expression of β-lactamases (e.g. PenA in B. cepacia complex and PenI in B. pseudomallei). Phylogenetic comparisons reveal that PenA and...
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