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Article

Insights into β-lactamases from Burkholderia species, two phylogenetically related yet distinct resistance determinants.

The Journal of biological chemistry - 28 Jun 2013

Papp-Wallace Krisztina M, Taracila Magdalena A, Gatta Julian A, Ohuchi Nozomi, Bonomo Robert A, Nukaga Michiyoshi

Abstract excerpt

Burkholderia cepacia complex and Burkholderia pseudomallei are opportunistic human pathogens. Resistance to β-lactams among Burkholderia spp. is attributable to expression of β-lactamases (e.g. PenA in B. cepacia complex and PenI in B. pseudomallei). Phylogenetic comparisons reveal that PenA and PenI are highly related. However, the analyses presented here reveal that PenA is an inhibitor-resistant carbapenemase,...

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PMID: 23658015
DOI: 10.1074/jbc.M113.458315
PMCID: PMC3696682

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