Article
A Novel Oncogenic Function of PRC2 Heterogeneity in Medulloblastoma
2021-12-02
Abstract excerpt
Intratumor epigenetic heterogeneity is emerging as a key mechanism underlying tumor evolution and drug resistance. Medulloblastomas, the most common childhood malignant brain tumor, are classified into four subtypes including SHH medulloblastomas, which are characterized by elevated SHH signaling and a cerebellum granule neuron precursor (CGNP) cell-of-origin. Medulloblastomas are highly associated with epigenetic...
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Identifiers and source
- Literature Corpus work
- 9c962fbc-f39d-5cd9-af39-9c1d82a06a02
- DOI
- 10.1101/2021.12.02.470979