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Molecular Heterogeneity and Cellular Diversity: Implications for Precision Treatment in Medulloblastoma

10 Mar 2020

Abstract excerpt

Medulloblastoma, the most common pediatric malignant brain tumor, continues to have a high rate of morbidity and mortality in childhood. Recent advances in cancer genomics, single-cell sequencing, and sophisticated tumor models have revolutionized the characterization and stratification of medulloblastoma. In this review, we discuss heterogeneity associated with four major subgroups of medulloblastoma (WNT, SHH,...

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PMID: 32164294
DOI: 10.3390/cancers12030643

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