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Article

Molecular Subgrouping of Medulloblastoma: Impact Upon Research and Clinical Practice

7 Jul 2015

Abstract excerpt

Medulloblastoma, the most common primary pediatric malignant brain tumor is a molecularly heterogeneous disease with different developmental origins, distinct phenotypes, diverse biological behaviour, and contrasting clinical outcomes. The current clinico-radiological risk-classification fails to take account of this heterogeneity and existent prognostic variability. It is widely accepted that dysregulation of...

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PMID: 26133181
DOI: 10.2174/1573396311666150702104030

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