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Article

Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice.

Scientific reports - 25 Feb 2021

Kundu Payel, Torres Eileen Ruth S, Stagaman Keaton, Kasschau Kristin, Okhovat Mariam, Holden Sarah, Ward Samantha, Nevonen Kimberly A, Davis Brett A, Saito Takashi, Saido Takaomi C, Carbone Lucia, Sharpton Thomas J, Raber Jacob

Abstract excerpt

Epigenetic mechanisms occurring in the brain as well as alterations in the gut microbiome composition might contribute to Alzheimer's disease (AD). Human amyloid precursor protein knock-in (KI) mice contain the Swedish and Iberian mutations (AppNL-F) or those two and also the Arctic mutation (AppNL-G-F). In this study, we assessed whether behavioral and cognitive performance in 6-month-old AppNL-F, AppNL-G-F, and...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33633159
DOI: 10.1038/s41598-021-83851-4
PMCID: PMC7907263

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