Altered Gut Microbiota Mediates the Association between APOE Genotype and Amyloid-β Accumulation in Middle-Aged Adults

Abstract excerpt

<h4>Importance</h4> The apolipoprotein E ( APOE ) ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD), yet the mechanisms linking APOE to amyloid-β (Aβ) pathology remain incompletely understood. Emerging evidence suggests that the gut microbiome may modulate neurodegeneration; however, its role as a mediator in the APOE–Aβ relationship remains unclear. <h4>Objective</h4> To evaluate wh...

Topics

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• Age Factors
• Aging
• Alzheimer Disease
• Apolipoproteins E
• Diet and metabolism studies
• Disease Models, Animal
• Gastrointestinal Microbiome
• Gut microbiota and health

Identifiers and source

Literature Corpus work

9eeddc17-e0ef-5d5d-8dfa-dd6f3f11c0cf

DOI

10.1101/2025.07.27.667048