Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein.

Molecular microbiology - 1 Aug 2005

Hendriks Edward F, Matthews Keith R

Abstract excerpt

The regulation of differentiation is particularly important in microbial eukaryotes that inhabit multiple environments. The parasite Trypanosoma brucei is an extreme example of this, requiring exquisite gene regulation during transmission from mammals to the tsetse fly vector. Unusually, trypanosomes rely almost exclusively on post-transcriptional mechanisms for regulated gene expression. Hence, RNA binding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to DNA-Binding Proteins
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Life Cycle Stages

Share to Mutation

Share to Protozoan Proteins

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 16045615
DOI: 10.1111/j.1365-2958.2005.04679.x
PMCID: PMC2686838

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein.PMID 16045615Read ↗

A novel CCCH protein which modulates differentiation of Trypanosoma brucei to its procyclic form.Semantic proximity Read ↗

Knockout of the CCCH zinc finger protein TcZC3H31 blocks Trypanosoma cruzi differentiation into the infective metacyclic formSemantic proximity Read ↗

Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development.Semantic proximity Read ↗

Genome-wide overexpression screen reveals a novel transcription termination factor in <i>Trypanosoma brucei</i>Semantic proximity Read ↗

TcZC3HTTP, a regulatory element that contributes to <i>Trypanosoma cruzi</i> cell proliferationSemantic proximity Read ↗

Identification of positive and negative regulators in the stepwise developmental progression towards infectivity in Trypanosoma bruceiSemantic proximity Read ↗

Transcriptomic analysis of N-terminal mutated <i>Trypanosoma cruzi</i> UBP1 knockdown underlines the importance of this RNA-binding protein in parasite developmentSemantic proximity Read ↗

Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing.Semantic proximity Read ↗

Chromosome-wide analysis of gene function by RNA interference in the african trypanosome.Semantic proximity Read ↗

Transcriptomic analysis of N-terminal mutated Trypanosoma cruzi UBP1 knockdown underlines the importance of this RNA-binding protein in parasite development.Semantic proximity Read ↗

Life-cycle differentiation in Trypanosoma brucei: molecules and mutants.Semantic proximity Read ↗

A limitation lifted: A conditional knockdown system reveals essential roles for Polo-like kinase and Aurora kinase 1 in Trypanosoma cruzi cell divisionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.