Article

Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4

2016-07-12

Abstract excerpt

<h4>ABSTRACT</h4> Protocadherins (Pcdhs) are cell adhesion and signaling proteins used by neurons to develop and maintain neuronal networks, relying on trans homophilic interactions between their extracellular cadherin (EC) repeat domains. We present the structure of the antiparallel EC1-4 homodimer of human PcdhYB3, a member of the γ subfamily of clustered Pcdhs. Structure and sequence comparisons of α, β, and...

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Literature Corpus work: 9c79b1f8-79d7-5ebe-b198-ea90f6375627
DOI: 10.1101/063289

Open publication

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