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Article

Comparative genomics and diversifying selection of the clustered vertebrate protocadherin genes.

Genetics - 1 Apr 2005

Wu Qiang

Abstract excerpt

To explain the mechanism for specifying diverse neuronal connections in the brain, Sperry proposed that individual cells carry chemoaffinity tags on their surfaces. The enormous complexity of these connections requires a tremendous diversity of cell-surface proteins. A large number of neural transmembrane protocadherin (Pcdh) proteins is encoded by three closely linked human and mouse gene clusters (alpha, beta,...

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Identifiers

PMID: 15744052
DOI: 10.1534/genetics.104.037606
PMCID: PMC1449604

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