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Article

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention

6 Jun 2018

Abstract excerpt

The complement system is an intricate defense network that rapidly removes invading pathogens. Although many complement regulators are present to protect host cells under homeostasis, the impairment of Factor H (FH) regulatory mechanism has been associated with several autoimmune and inflammatory diseases. To understand the dynamics involved in the pivotal balance between activation and regulation, we have...

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PMID: 29874282
DOI: 10.1371/journal.pone.0198644

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