Article
The effect of interleukin-21 on HBV-related hepatocellular carcinoma, from the perspective of genetics.
World journal of surgical oncology - 16 Apr 2026
Wang Xi, Yao Yanping, Chen Xu, Qiu Jun, Fu Hailong
Abstract excerpt
BACKGROUND: Hepatocellular carcinoma (HCC) represents a major global health burden, with chronic hepatitis B virus (HBV) infection being its predominant cause. However, only a fraction of chronic HBV carriers progress to HCC, suggesting a critical role for host genetic susceptibility. Interleukin...
Topics
- Humans
- Carcinoma, Hepatocellular
- Liver Neoplasms
- Interleukins
- Interleukin-21
- Female
- Case-Control Studies
- Polymorphism, Single Nucleotide
- Male
- Middle Aged
- Genetic Predisposition to Disease
- Hepatitis B virus
- Prognosis
- Genotype
- Hepatitis B, Chronic
- Adult
- Follow-Up Studies
- Polymerase Chain Reaction