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Article

The effect of interleukin-21 on HBV-related hepatocellular carcinoma, from the perspective of genetics.

World journal of surgical oncology - 16 Apr 2026

Wang Xi, Yao Yanping, Chen Xu, Qiu Jun, Fu Hailong

Abstract excerpt

BACKGROUND: Hepatocellular carcinoma (HCC) represents a major global health burden, with chronic hepatitis B virus (HBV) infection being its predominant cause. However, only a fraction of chronic HBV carriers progress to HCC, suggesting a critical role for host genetic susceptibility. Interleukin-21 (IL-21) is a key immunomodulatory cytokine implicated in anti-tumor immunity, yet the association between IL-21...

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Identifiers

PMID: 41992330
DOI: 10.1186/s12957-026-04360-0
PMCID: PMC13224504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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