Article

Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells

2024-10-13

Abstract excerpt

<h4>ABSTRACT</h4> The rate of spontaneous action potentials (APs) generated by sinoatrial node cells (SANC) is regulated by local Ca 2+ release (LCR) from the sarcoplasmic reticulum via Ca 2+ release channels (ryanodine receptors, RyRs). LCR events propagate and self-organize within the network of RyR clusters (Ca release units, CRUs) via Ca-induced-Ca-release (CICR) that depends on CRU sizes and locations: whi...

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Literature Corpus work: 9c5c2672-e1af-5b93-944c-e3aaf278e6b3
DOI: 10.1101/2024.10.09.617454

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