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Disorder in Ca <sup>2+</sup> Release Unit Locations Confers Robustness but Cuts Flexibility of Heart Pacemaking

2021-11-20

Abstract excerpt

Excitation-contraction coupling kinetics are dictated by the rate and rhythm of the excitations generated by sinoatrial-nodal cells. These cells generate local Ca releases (LCRs) that activate Na/Ca exchanger current, which accelerates diastolic depolarization and determines the rate and rhythm of the excitations. The LCRs are generated by clusters of ryanodine receptors, Ca release units (CRUs), residing in the s...

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Literature Corpus work
f0916285-2343-529b-9fed-ca6392530b76
DOI
10.1101/2021.11.19.469309
Open publication

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Disorder in Ca <sup>2+</sup> Release Unit Locations Confers Robustness but Cuts Flexibility of Heart PacemakingDOI 10.1101/2021.11.19.469309
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